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-synuclein, that is a primary part of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, that is an E3 ubiquitin ligase and causes endoplasmic reticulum (ER) strain, propose that dysfunction in the intracellular proteinase devices, including ubiquitin-proteasome procedure or lysosomal procedure, which eliminates unnecessary harmful protei